Formulation: A solid
Formal Name: 3',5'-difluoro-4'-((6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamido)methyl)-[1,1'-biphenyl]-3-sulfonyl fluoride
Purity: ≥98%
Formula Markup: C25H18F3N3O4S
Formula Weight: 513,5
Shelf life (days): 1095
Notes: WDR5-MYC probe 12 is an inhibitor of the protein-protein interaction between the master transcription factor Myc and WD repeat domain 5 (WDR5; IC50 = 0.39 µM).{72194} It reduces mRNA expression of the Myc and WDR5 co-binding target genes ribosomal protein L17 (RPL17), RPL23, RPL35, and RPL37A in HL-60 cells. WDR5-MYC probe 12 also inhibits the growth of HL-60, NB4, Ramos (RA 1), COR-L279, and NCI H520 cancer cells (GI50s = 4.2-9.4 µM).