XY-52

Product Description: XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model[1].

Applications: COVID-19-immunoregulation

Formula: C30H37N5O2

References: [1]Yuan X, et al. Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors. ACS Pharmacol Transl Sci. 2023 Aug 16;6(9):1275-1287.

Molecular Weight: 499.65

Compound Purity: 99.77

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Interleukin Related

• Artikelnummer: MEXHY-155193-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-155193-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK