PAMAM Dendrimer G2.0 Amidoethanol (water solution)

Formulation: A solution in water

Formula Markup: [NH2(CH2)2NH2]:(G=2);dendri PAMAM(NHCH2CH2OH)16

Formula Weight: 3271,9

Shelf life (days): 730

Notes: PAMAM dendrimer G2.0 amidoethanol (PAMAM G2.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vitro.{65905,72181} It is approximately 29.4 Å in diameter in water and has 16 surface groups.{72180} PAMAM G2.0 amidoethanol is an antagonist of the pore-forming channel binary anthrax toxin protective antigen 63 (PA63) in lipid bilayers (IC50 = 142 nM).{51557} It inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells when used at a concentration of 100 µM.{72182} PAMAM G2.0 amidoethanol enhances the water solubility of the antibiotic erythromycin (Item No. 16486) and increases the antifungal activity of clotrimazole (Item No. 15278) against Candida.{65905,72181} Fragmentation of PAMAM G2.0 amidoethanol with hydrogen peroxide produces a fluorescent unsaturated hydroxylamine, which selectively detects hypochlorite over several other reactive oxygen species (ROS) and has been used to detect intracellular hypochlorite levels in RAW 246.7 macrophages.{72183}

• Artikelnummer: CAY39111-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39111-1
• Verpackungseinheit: 1 g
• Mengeneinheit: STK