Shelf life (days): 1460.0
Formulation: A powder
Formal Name: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraen-1-yl]-2H-pyran-2-one, monosodium salt
Purity: ≥95%
Formula Markup: C19H26O9P / Na
Formula Weight: 452.4
CAS Number: 87860-39-7
Notes: Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively).{23816,23817} It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B.{23816,21678} Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation.{18481} On a related note, fostriecin was first identified as an antitumor antibiotic.{23815}
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