Product Description: FS102 is a selective Fc fragment with antigen binding (Fcab) that targets HER2 with a KD value of 0.8 nM. FS102 induces the degradation of HER2, activates Caspase 3/7 and disrupts the integrity of the cell membrane, triggering apoptosis of tumor cells. FS102 is promising for research of cancers such as breast cancer, gastric cancer, and colorectal cancer[1][2].
Formula: N/A
References: [1]Batey S, et al. Abstract B123: Preclinical evaluation of FS102: A HER2-specific Fcab with a novel mechanism of action[J]. Molecular Cancer Therapeutics, 2013, 12(11_Supplement): B123-B123./[2]Leung K M, et al. A HER2-specific modified Fc fragment (Fcab) induces antitumor effects through degradation of HER2 and apoptosis[J]. Molecular Therapy, 2015, 23(11): 1722-1733.
Molecular Weight: N/A
Research Area: Cancer
Target: Caspase;EGFR
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