Product Description: Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs)[1][2][3][4][5].
Applications: COVID-19-immunoregulation
Formula: C10H8N4O5
References: [1]Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70./[2]Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30./[3]Pustenko A, et al. The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1011-1020./[4]Osterman IA, et al. Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors[J]. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7481-7489./[5]Sapegin A, et al. Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria. Biomedicines. 2022 Sep 6;10(9):2203.
CAS Number: 1672-88-4
Molecular Weight: 264.19
Compound Purity: 99.84
Research Area: Cancer; Infection
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL
Target: Antibiotic;Bacterial;Carbonic Anhydrase
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