FzM1, CAS 1680196-54-6

Product Description: FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade[1].

Applications: Cancer-programmed cell death

Formula: C21H16N2O2S

References: [1]Gennaro Riccio, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.

CAS Number: 1680196-54-6

Molecular Weight: 360.43

Compound Purity: 98.62

Research Area: Cancer

Solubility: DMSO : 62.5 mg/mL (ultrasonic)

Target: Wnt;β-catenin

• Artikelnummer: MEXHY-116553-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-116553-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK