Product Description: γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3].
Applications: Cancer-programmed cell death
Formula: C39H54N10O13S
References: [1]He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. /[2]Gong M, et al. Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3. Food Chem Toxicol. 2024 Jun;188:114665. /[3]Garcia J, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Dec;86:41-55.
CAS Number: 21150-23-2
Molecular Weight: 902.97
Compound Purity: 90.0
Research Area: Cancer
Solubility: DMSO : 1 mg/mL (ultrasonic;warming)
Target: ADC Cytotoxin;DNA/RNA Synthesis
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