Product Description: G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
Applications: Cancer-programmed cell death
Formula: C25H16ClN7O3S
References: [1]Voronkov A, et al. Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem. 2013 Apr 11;56(7):3012-23./[2]Norum JH, et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018 Jan 9;51(1):3./[3]Xin Chen, et al. Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. PLoS One. 2017 Sep 6;12(9):e0184068.
CAS Number: 1380672-07-0
Molecular Weight: 529.96
Compound Purity: 99.24
Research Area: Cancer
Solubility: DMSO : ≥ 30 mg/mL
Target: PARP
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