Target: GABA A Receptor
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N87/25 (Formerly sold as S87-25)
Immunogen: Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta 3
Swiss-Prot: P63080
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~55kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.
Cellular Localization: Cell Membrane / Cell Junction / Synapse / Postsynaptic Cell Membrane
Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).
References: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136.2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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