Product Description: Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer[1][2].
Applications: Cancer-programmed cell death
Formula: C38H46O8
References: [1]Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260./[2]Huang T, et al. Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncol Rep. 2019 Mar;41(3):1700-1706.
CAS Number: 173932-75-7
Molecular Weight: 630.77
Compound Purity: 99.94
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Histone Methyltransferase
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