Description: Ganglioside GM1-binding peptide sp3 is a synthetically engineered peptide that specifically binds to the pentasaccharide region of GM1 ganglioside. The dynamic transitions of Ganglioside GM1-binding peptide sp3 may play a crucial role in the functions of GM1 as a receptor for various ligands, such as in the conventional pathway of cholera toxin infection. This peptide is useful for studies on the interactions between GM1 and its ligands.