Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-valyl-L-cysteinyl-L-tyrosyl-L-a-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-L-arginine, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C70H107N19O19S / XCF3COOH
Formula Weight: 1550.78124
CAS Number: 197250-15-0
Notes: Gap 26 is a connexin-mimetic peptide that corresponds to amino acids 63-75 of extracellular loop 1 in connexin 43.{67015} It inhibits phenylephrine-induced rhythmic contractile activity in isolated rabbit superior mesenteric arterial strips (IC50 = 28.4 µM). Gap 26 (0.25 mg/ml) inhibits photoliberated Ins(1,4,5)-P3-induced ATP release in ECV304 cells.{67016} It decreases the infarct size in a rat model of myocardial infarction induced by left coronary artery occlusion when administered at doses of 0.5, 1, and 10 µg/kg.{67017}
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