Garcinone D, CAS 107390-08-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Purity: ≥95%

Formula Markup: C24H28O7

Formula Weight: 428.47492

CAS Number: 107390-08-9

Notes: Garcinone D is a xanthone that has been found in G. mangostana and has diverse biological activities.{54166} It increases proliferation of C17.2 neural progenitor cells (NPCs) when used at a concentration of 5 µM, an effect that can be reduced by inhibition of the antioxidative transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). It increases phosphorylation of STAT3 and cyclin D1 and the protein levels of Nrf2 and heme oxygenase-1 (HO-1) in a concentration-dependent manner. Garcinone D (3 µM) inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) in vitro and inhibits beta-secretase 1 (BACE1) by 62.7% when used at a concentration of 100 µM.{54167} It scavenges peroxynitrite radicals with an IC50 value of 26.4 µM.{54168}

• Artikelnummer: CAY30906-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30906-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK