Product Description: Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2].
Applications: Neuroscience-Neurodegeneration
Formula: C24H28O7
References: [1]Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12./[2]Nauman MC, et al. Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana): a structure-activity relationship study. Nat Prod Res. 2021 Dec;35(23):5429-5433.
CAS Number: 107390-08-9
Molecular Weight: 428.47
Compound Purity: 99.88
Research Area: Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Keap1-Nrf2;Reactive Oxygen Species;STAT
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