Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride
Purity: ≥98%
Formula Markup: C28H32F2N2O / 2HCl
Formula Weight: 523.5
CAS Number: 67469-78-7
Notes: GBR 12909 is a potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM).{25553,25555} It is more than 100-fold less effective at blocking serotonin or noradrenaline uptake.{25553,25555} GBR 12909 effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.{25553,25554} GBR 12909 also inhibits pyrilamine binding to the histamine H1 receptor (IC50 = 18 nM) but poorly inhibits ligand binding to dopamine, adrenergic, acetylcholine, serotonin, and γ-aminobutyric acid receptors.{25555} It also blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).{25552}
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