Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2S)-1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-2-hydroxy-1-propanone
Purity: ≥98%
Formula Markup: C23H30N8O3S
Formula Weight: 498.6
CAS Number: 1032754-93-0
Notes: GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively, in cell-free assays.{29877,29878} It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases.{29877,29878} GDC-0980 induces cell cycle arrest or apoptosis in a range of cancer cell lines.{29878} It is effective in vivo, suppressing the growth of a number of tumor xenografts in mice and enhancing the antitumor activity of docetaxel (Item No. 11637) in mice.{29878}
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