GDC-2394, CAS 2238822-07-4

GDC-2394, CAS 2238822-07-4
Artikelnummer
MEXHY-148258-10.1
Verpackungseinheit
10 mM/1 ml
Hersteller
MedChemExpress

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Product Description: GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC50s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation[1][2].

Applications: COVID-19-immunoregulation

Formula: C20H25N5O4S

References: [1]McBride C, et al. Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor. J Med Chem. 2022 Oct 24. /[2]Stafford, et al. Preparation of hexahydroindacenylcarbamoyldihydropyrazolooxazinesulfonamide derivatives and analogs for use as interleukin-1 activity inhibitors: World Intellectual Property Organization, WO2018136890[P]. 2018-07-26.

CAS Number: 2238822-07-4

Molecular Weight: 431.51

Compound Purity: 99.54

Research Area: Inflammation/Immunology

Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Caspase;Interleukin Related;NOD-like Receptor (NLR)
Mehr Informationen
Artikelnummer MEXHY-148258-10.1
Hersteller MedChemExpress
Hersteller Artikelnummer HY-148258-10.1
Verpackungseinheit 10 mM/1 ml
Mengeneinheit STK
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