Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,5-dihydroxy-benzoic acid
Purity: ≥98%
Formula Markup: C7H6O4
Formula Weight: 154.12014
CAS Number: 490-79-9
Notes: Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}
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