Shelf life (days): 1460.0
Formulation: A solid
Formal Name: [glycyl-?N-L-histidyl-?N,?N3-L-lysinato(2-)]-copper, monoacetate
Purity: ≥95%
Formula Markup: C14H22CuN6O4 / C2H4O2
Formula Weight: 462.0
CAS Number: 300801-03-0
Notes: GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities.{45528,45529,45530} It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM.{45529,45531,45528} GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats.{45532} It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 µM.{45530} GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
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