Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3’,2’:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Purity: ≥98%
Formula Markup: C20H24O10
Formula Weight: 424.4
CAS Number: 15291-77-7
Notes: Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
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