Description: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: DTA-1
Immunogen: Mouse CD25 CD4 T cells
Antibody Reactivity: GITR/Tnfrsf18
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Clin Cancer Res (2013) 19(5): 1044-53. (functional studies)
- J Immunol (2019) 203:864-872. (Flow)
Entrez Gene ID: 21936
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)
Antibody Application Notes: Flow cytometry: 0.5-1 ug/million cells in 0.1 mL/Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Optimal dilution for a specific application should be determined by user
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