Target: GluR1
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N355/1 (Formerly sold as S355-1)
Immunogen: Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1
Swiss-Prot: P19490
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~100kDa. Does not cross-react with GluR2.
Cellular Localization: Cell Membrane / Endoplasmic Reticulum / Cell Junction
Scientific Background: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).
References: 1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218.2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561.3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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