Target: GluN1
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N308/48 (Formerly sold as S308-48)
Immunogen: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
Swiss-Prot: P35439
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~105kDa.
Cellular Localization: Cell Membrane / Cell Junction / Synapse / Postsynaptic Cell Membrane
Scientific Background: The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function (1). The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits (the subunits are also called glutamate-binding NMDA receptor subunits or GluN for short); two obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.
References: 1. Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303.2. Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547.3. Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299-25307.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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