Product Description: GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) [1].
Applications: Cancer-Kinase/protease
Formula: C28H21F4N5O2
References: [1]Albaugh, P. et al. Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS MEDICINAL CHEMISTRY LETTERS, 2012; 3 (2): 140/[2]Aristizabal Prada ET, et al. Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors. Endocr Relat Cancer. 2018 May;25(5):547-560.
CAS Number: 1033769-28-6
Molecular Weight: 535.49
Compound Purity: 99.65
Research Area: Cancer
Solubility: DMSO : ≥ 32 mg/mL
Target: Trk Receptor
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