GNF4877, CAS 2041073-22-5

Product Description: GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells)[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C25H27FN6O4

References: [1]Shen W, et al. Inhibition of DYRK1A and GSK3β induces human β-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.

CAS Number: 2041073-22-5

Molecular Weight: 494.52

Compound Purity: 99.41

Research Area: Metabolic Disease

Solubility: DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target: DYRK;GSK-3

• Artikelnummer: MEXHY-129492-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-129492-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK