Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: 5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione
Purity: ≥95%
Formula Markup: C19H16BrNO3S
Formula Weight: 418.3
CAS Number: 870554-67-9
Notes: Full activation of peroxisome proliferator-activated receptor γ (PPARγ), e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema.{21030} GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone (Item No. 71740).{21030} Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling.{21030} However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα.{21030}
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