Product Description: GR203040 is an orally active NK1 receptor antagonist with a pKi of 10.3. GR203040 shows potent antiemetic activity[1].
Applications: Neuroscience-Neuromodulation
Formula: C20H26Cl2N6O
References: [1]Ward P, et al. Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity. J Med Chem. 1995 Dec 22;38(26):4985-92.
CAS Number: 168398-02-5
Molecular Weight: 437.37
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Neurokinin Receptor