Product Description: GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C20H26Cl2F2N4O
References: [1]Michel AD, et al. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol. 2008 Feb;153(4):737-50. /[2]Svobodova I, et al. Circadian ATP Release in Organotypic Cultures of the Rat Suprachiasmatic Nucleus Is Dependent on P2X7 and P2Y Receptors. Front Pharmacol. 2018 Mar 6;9:192.
CAS Number: 1019779-04-4
Molecular Weight: 447.35
Compound Purity: 98.03
Research Area: Neurological Disease
Solubility: DMSO : 20 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: P2X Receptor
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