Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine
Purity: ≥95%
Formula Markup: C28H37NO9
Formula Weight: 531.6
CAS Number: 26833-85-2
Notes: Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.{25658} It immobilizes ribosomes immediately after the initiation of translation.{25658,25659} While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.{25660,25662,25661} The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.{25659}