Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide
Purity: ≥98%
Formula Markup: C18H21N5O3
Formula Weight: 355.4
CAS Number: 349085-38-7
Notes: Transient receptor potential cation channel A1 (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds.{14717,21768,20044} HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50s = 6.2 and 5.3 μM, respectively).{21768} It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels.{21768} HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection.{21768,21766,21765,21767} Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.{21766,21767}
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