HIF-2α Antagonist 2, CAS 1422955-31-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

Purity: ≥98%

Formula Markup: C12H6ClFN4O3

Formula Weight: 308.7

CAS Number: 1422955-31-4

Notes: HIF-2α antagonist 2 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α) PAS-B domain heterodimerization.{53889} It binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2α antagonist 2 (0.1-30 µM) decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells.

• Artikelnummer: CAY16971-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16971-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK