Homoharringtonine, CAS 26833-87-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]cephalotaxine

Purity: ≥98%

Formula Markup: C29H39NO9

Formula Weight: 545.6

CAS Number: 26833-87-4

Notes: An alkaloid; inhibits diphenylalanine formation by rabbit reticulocyte and human placental ribosomes in cell-free assays; binds to human 80S ribosomes (Kd = 38.8 nM); reduces the viral load in vitro and in vivo and prevents severe symptoms in porcine and chicken models of PEDV and NDV, respectively; reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 2.55 and 2.14 µM, respectively); inhibits the growth of P. falciparum in cultured in human erythrocytes (IC50 = 4 nM); inhibits the proliferation of Jurkat acute T cell leukemia (IC50 = 9 nM) and K562 CML cells (IC50 = 408 μg/ml); decreases the number of peripheral leukemia stem cells and increases survival in CML and B-ALL mouse models

• Artikelnummer: CAY14631-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14631-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK