HPOB, CAS 1429651-50-2

Product Description: HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6[1].

Applications: Cancer-programmed cell death

Formula: C17H18N2O4

References: [1]Lee JH et al. Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9./[2]Li ZY et al. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochem Int. 2016 Oct;99:239-51.

CAS Number: 1429651-50-2

Molecular Weight: 314.34

Compound Purity: 99.80

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Apoptosis;HDAC

• Artikelnummer: MEXHY-19747-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19747-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK