HS-38, CAS 1030203-81-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide

Purity: ≥98%

Formula Markup: C14H12ClN5O2S

Formula Weight: 349.8

CAS Number: 1030203-81-6

Notes: A DAPK1 (IC50 = 200 nM) and DAPK3 inhibitor; selectively binds to DAPK1, DAPK2, and DAPK3 (Kds = 300, 79, and 280 nM, respectively) over Pim-1, Pim-2, and Pim-3 (Kds = 1,800, 6,500, and 810 nM, respectively) but does inhibit Pim-3 (IC50 = 200 nM); inhibits phosphorylation of RLC20 in primary human coronary artery smooth muscle cells at 10 µM; reduces phenylephrine-induced contractions in isolated mouse aortic rings and increases the time to reach 50% maximal contractions in calyculin A-stimulated isolated rat caudal arterial smooth muscle strips at 10 and 100 µM, respectively

• Artikelnummer: CAY42246-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42246-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK