Hydroxy desmethyl Bosentan, CAS 253688-62-9

Product Description: Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].

Applications: Neuroscience-Neuromodulation

Formula: C26H27N5O7S

References: [1]Lepri S, et al. Metabolism study and biological evaluation of bosentan derivatives. Eur J Med Chem. 2016 Oct 4;121:658-670./[2]Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.

CAS Number: 253688-62-9

Molecular Weight: 553.59

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Drug Metabolite

• Artikelnummer: MEXHY-135390-500UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-135390-500UG
• Verpackungseinheit: 500 μg
• Mengeneinheit: STK