Product Description: Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
Applications: COVID-19-anti-virus
Formula: C14H18ClN3O3S
References: [1]Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1./[2]Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7./[3]Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.
CAS Number: 155558-32-0
Molecular Weight: 343.83
Compound Purity: 98.99
Research Area: Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility: DMSO : 30 mg/mL (ultrasonic)/H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: ROCK
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