Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dione
Purity: ≥98%
Formula Markup: C30H24O9
Formula Weight: 528.50616
CAS Number: 123940-54-5
Notes: Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.{45497,45498} It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.{45497} It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).{45498}
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