(±)-Ibutilide (hemifumarate), CAS 122647-32-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1)

Purity: ≥98%

Formula Markup: C20H36N2O3S / 1/2C4H4O4

Formula Weight: 442.6

CAS Number: 122647-32-9

Notes: (±)-Ibutilide is a class III antiarrhythmic agent.{55269} It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM.{55273} (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular cells.{55270} It decreases ventricular fibrillation induced by the ATP-dependent potassium channel activator pinacidil (Item No. 15416) in Langendorff isolated perfused rabbit hearts when used at concentrations ranging from 3 to 30 µM.{55271} (±)-Ibutilide (15 µg/kg, i.v.) increases the effective refractory period (ERP) of the left and right atrium in anesthetized pigs.{55272} It prevents rapid pacing-induced atrial flutter in dogs when administered orally at doses ranging from 0.25 to 5 mg/kg. Formulations containing ibutilide have been used in the treatment of atrial arrhythmias.

• Artikelnummer: CAY15011-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15011-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK