Product Description: IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM.
Applications: Cancer-Kinase/protease
Formula: C22H19N7O
References: [1]Sadhu C, et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003 Mar 1;170(5):2647-54./[2]Zheng L, et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):368-77./[3]El-Hashim AZ, et al. Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model. Sci Rep. 2017 Aug 30;7(1):9919.
CAS Number: 371242-69-2
Molecular Weight: 397.43
Compound Purity: 99.83
Research Area: Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic)
Target: PI3K
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