Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole, monohydrochloride
Purity: ≥95%
Formula Markup: C11H12N2O2 / HCl
Formula Weight: 240.6859
CAS Number: 79944-56-2
Notes: An antagonist of α2-adrenergic and imidazoline I1 and I2 receptors (IC50s = 69, 66, and 61 nM, respectively); selectively binds to α2A- and α2C-ARs over α2B-ARs (Kds = 67, 69, and 407 nM, respectively), as well as α2-ARs over α1-ARs (IC50s = 0.7 and 4,000 µM, respectively); increases mean arterial pressure and decreases heart rate in rabbits from 0.1-5 mg/kg; reverses the anti-hyperalgesic activity of 2-BFI in rat models of inflammatory and neuropathic pain and the antidepressant-like activity of 2-BFI in the tail suspension test in mice; reduces L-DOPA-induced dyskinesia in a cynomolgus monkey model of MPTP-induced Parkinson’s disease at 7.5 and 10 mg/kg
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