Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: 1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid
Purity: ≥95%
Formula Markup: C15H18N2O5
Formula Weight: 306.3
CAS Number: 1160927-48-9
Notes: IDE1 is a small molecule capable of inducing definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 125.5 nM in vitro) by activating the TGF-β signaling pathway.{17965} IDE1-derived endodermal cells injected into E8.75 mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation.{17965} Furthermore, when treated with either indolactam V (Item No. 14647) or a standard regimen of the growth factor FGF-10, retinoic acid, and hedgehog inhibitors, IDE1-induced endodermal cells can form Pdx1-expressing pancreatic progenitors.{17965}
Deutsch
English
