Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: a-(4-hydroxyphenyl)-ß-methyl-4-(phenylmethyl)-1-piperidineethanol, 2R,3R-dihydroxybutanedioate (2:1)
Purity: ≥98%
Formula Markup: C21H27NO2 / 1/2C4H6O6
Formula Weight: 400.5
CAS Number: 23210-58-4
Notes: Ifenprodil is an antagonist of NR1A/NR2B subunit-containing NMDA receptors (IC50 = 340 nM).{57344} It is selective for NR1A/NR2B subunit-containing NMDA receptors over those containing NR1A/NR2A or NR1A/NR2C subunits (IC50s = 20 and >100 µM, respectively) but also binds to sigma 1 (σ1) receptors, emopamil binding protein, and fungal C-8 sterol isomerase/ERG2 (Kis = 2, 5, and 1 nM, respectively), as well as α1 adrenergic receptors (α1-AR; IC50 = 110 nM), and the serotonin receptor types 5-HT1A and 5-HT2 (IC50s = 238 and 610 nM, respectively).{57345,24575,57346} Ifenprodil inhibits infection of MDCK cells by H1N1 and H3N2 influenza isolates in vitro (EC50s = 6.6 and 16.9 µM, respectively).{57347} It increases the production of NGF, BDNF, and GDNF in primary mouse astrocytes when used at a concentration of 150 µM.{57348} Ifenprodil also reduces maximal electroshock seizures in mice (ED50s = 16 and 7 mg/kg, respectively).{57345}
Deutsch
English
