Product Description: IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1)[1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively[2].
Applications: Cancer-programmed cell death
Formula: C19H15N3OS
References: [1]Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9./[2]Jiangxue Han, et al. IMB-XH1 identified as a novel inhibitor of New Delhi metallo-β-lactamase-1.
CAS Number: 292057-76-2
Molecular Weight: 333.41
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: Bacterial;Bcl-2 Family;Beta-lactamase