Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid, ethyl ester
Purity: ≥95% (mixture of isomers)
Formula Markup: C15H15NO5S2
Formula Weight: 353.41534
CAS Number: 310456-65-6
Notes: IMR-1 is an inhibitor of mastermind-like 1 (Maml1) recruitment to chromatin.{35889} It binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1, but not Notch1, to chromatin. It inhibits colony formation in the Notch-dependent cell lines SUM149, SUM159, and HT-1080, but not the Notch-independent cell lines T47D, MCF-7, and H23 when used at concentrations of 15 and 45 µM. IMR-1 (15 mg/kg) decreases the expression of the Notch target genes HES1, HEYL, and NOTCH3 and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model.
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