Notes: INCB 13739 is an inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1; IC50 = 3.2 nM).{72228} It is greater than 1,000-fold selective for 11β-HSD1 over 11β-HSD2, the mineralocorticoid receptor, and the glucocorticoid receptor at 5 µM. INCB 13739 inhibits 11β-HSD1 activity in peripheral blood mononuclear cells (PBMCs; IC50 = 1.1 nM).