Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinyl-2,4,5,6-d4-methyl-d2)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C36H41D6N5O4
Formula Weight: 619.82604
CAS Number: 185897-02-3
Notes: Indinavir-d6 is intended for use as an internal standard for the quantification of indinavir (Item No. 15150) by GC- or LC-MS. Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM).{49495} It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively).{24228} Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM).{49495} Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.
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