Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1H-indol-3-yl-2,4,5,6,7-d5 sulfate, potassium salt
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C8HD5NO4S / K
Formula Weight: 256.33218
CAS Number: 1644451-34-2
Notes: Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate (Item No. 16926) by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan (Item No. 29600).{27740} It is formed via sulfation of indoxyl, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver.{58559,27740} Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay).{58560} It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells.{58561} Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells.{58562} It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.{58561}