INDY, CAS 1169755-45-6

Product Description: INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2].

Applications: Cancer-Kinase/protease

Formula: C12H13NO2S

References: [1]Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86./[2]Pozo N, et al. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastomagrowth. J Clin Invest. 2013 Jun;123(6):2475-87.

CAS Number: 1169755-45-6

Molecular Weight: 235.30

Compound Purity: 99.51

Research Area: Cancer

Solubility: DMSO : ≥ 33.33 mg/mL

Target: DYRK

• Artikelnummer: MEXHY-108476-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-108476-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK