INH6, CAS 1001753-24-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide

Purity: ≥98%

Formula Markup: C19H18N2OS

Formula Weight: 322.4

CAS Number: 1001753-24-7

Notes: INH6 is an inhibitor of the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine-threonine kinase Nek2, which together regulate mitotic spindle formation.{38094,38095} It inhibits proliferation in human breast, cervical, and leukemia cell lines with IC50 values of 1.7 and 2.1, 2.4, and 2.5 µM, respectively, for MDA-MB-231 and MDA-MB-468, HeLa, and K562 cells.{38094} INH6 co-precipitates with cellular Hec1, reduces Nek2 protein levels when administered to HeLa cells at 6.25 µM, disrupts spindle formation, and induces apoptosis.

• Artikelnummer: CAY21772-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21772-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK